Human TRAIL R2 / DR5 / TNFRSF10B Protein, Fc Tag, Unconjugated

Produktübersicht

• Artikelname: Human TRAIL R2 / DR5 / TNFRSF10B Protein, Fc Tag, Unconjugated
• Artikelnummer: ABS-TR2-H5255-100UG
• Hersteller Artikelnummer: TR2-H5255-100ug
• Alternativnummer: ABS-TR2-H5255-100UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNFrelated apoptosisinducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNFreceptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR5 is widely expressed in adult and fetal tissues, very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAILR2 / TNFRSF10B recruits caspase8 to the activated receptor. The resulting deathinducing signaling complex (DISC) performs caspase8 proteolytic activation which initiates the subsequent cascade of caspases (aspartatespecific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NFkappaB. DR5 is essential for ER stressinduced apoptosis and is regulated by p53/TP53. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 40.4 kDa
• Tag: C-Fc
• NCBI: 003833
• Puffer: 50 mM Tris, 100 mM NaCl, pH7.5
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: TRAIL R2

Bilder

Immobilized Human TRAIL, Mouse IgG2a Fc Tag at 5 µg/mL (100 µL/well) can bind Human TRAIL R2, Fc Tag (Cat. No. TR2-H5255) with a linear range of 0.6-20 ng/mL (QC tested).

TR2-H5255-100ug

Human TRAIL R2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.