Biotinylated Human TRAIL R2 / DR5 / TNFRSF10B Protein, Avitag(TM),His Tag (MALS verified)

Produktübersicht

• Artikelname: Biotinylated Human TRAIL R2 / DR5 / TNFRSF10B Protein, Avitag(TM),His Tag (MALS verified)
• Artikelnummer: ABS-TR2-H82E6-200UG
• Hersteller Artikelnummer: TR2-H82E6-200ug
• Alternativnummer: ABS-TR2-H82E6-200UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Biotin

Produktbeschreibung

Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNFrelated apoptosisinducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNFreceptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR5 is widely expressed in adult and fetal tissues, very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAILR2 / TNFRSF10B recruits caspase8 to the activated receptor. The resulting deathinducing signaling complex (DISC) performs caspase8 proteolytic activation which initiates the subsequent cascade of caspases (aspartatespecific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NFkappaB. DR5 is essential for ER stressinduced apoptosis and is regulated by p53/TP53. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 16.9 kDa
• Tag: C-Avi & C-6*His
• NCBI: 14763
• Puffer: PBS, pH7.4
• Reinheit: 90%
• Formulierung: Powder
• Target-Kategorie: TRAIL R2

Bilder

Biotinylated Human TRAIL R2, Avitag,His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.