Human TRAIL / TNFSF10 Protein, His Tag, active trimer (MALS verified), Unconjugated

Produktübersicht

• Artikelname: Human TRAIL / TNFSF10 Protein, His Tag, active trimer (MALS verified), Unconjugated
• Artikelnummer: ABS-TRL-H5243-100UG
• Hersteller Artikelnummer: TRL-H5243-100ug
• Alternativnummer: ABS-TRL-H5243-100UG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

TRAIL, also known as TNFSF10, APO2L, Apo2L, CD253, TL2, TRAIL, TNLG6A and TNF superfamily member 10. The TRAIL gene as a drug target, induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. TRAIL also binds the receptors DcR1 and DcR2, which do not contain a cytoplasmic domain (DcR1) or contain a truncated death domain (DcR2). DcR1 functions as a TRAILneutralizing decoyreceptor. The cytoplasmic domain of DcR2 is functional and activates NFkappaB. In cells expressing DcR2, TRAIL binding therefore activates NFkappaB, leading to transcription of genes known to antagonize the death signaling pathway and/or to promote inflammation. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 61.8 kDa
• Tag: N-10*His
• NCBI: 50591
• Puffer: PBS, pH7.4
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: TRAIL

Bilder

Immobilized Human TRAIL Protein, His Tag (Cat. No. TRL-H5243) at 5 µg/mL (100 µL/well) can bind Human TRAIL R2, Fc Tag (Cat. No. TR2-H5255) with a linear range of 0.2-2 ng/mL (QC tested).

Immobilized Human TRAIL Protein, His Tag (Cat. No. TRL-H5243) at 5 µg/mL (100 µL/well) can bind Human TRAIL R1, Fc Tag (Cat. No. TR1-H5254) with a linear range of 0.3-5 ng/mL (Routinely tested).

Human TRAIL Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.