Rhesus macaque Transferrin Protein, His Tag (MALS verified), Unconjugated, Human
Artikelnummer:
ABS-TRN-R52H3-1MG
Hersteller Artikelnummer:
TRN-R52H3-1mg
Alternativnummer:
ABS-TRN-R52H3-1MG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Monkey
Konjugation:
Unconjugated
Transferrin is also known as Serotransferrin, Beta1 metalbinding globulin, TF, and is ironbinding blood plasma glycoproteins that control the level of free iron in biological fluids. Although iron bound to transferrin is less than 0.1% (4?mg) of the total body iron, it is the most important iron pool, with the highest rate of turnover (25?mg/24 h). The affinity of transferrin for Fe(III) is extremely high (1023 M?1 at pH 7.4) but decreases progressively with decreasing pH below neutrality.When not bound to iron, it is known as ''apotransferrin. In humans, transferrin consists of a polypeptide chain containing 679 amino acids. It is a complex composed of alpha helices and beta sheets to form two domains (the first situated in the Nterminus and the second in the Cterminus). The N and C terminal sequences are represented by globular lobes and between the two lobes is an ironbinding site. The liver is the main source of manufacturing transferrin, but other sources such as the brain also produce this molecule . Transferrin is also associated with the innate immune system. Transferrin is found in the mucosa and binds iron, thus creating an environment low in free iron that impedes bacteria survival in a process called iron withholding. The level of transferrin decreases in inflammation. The metal binding properties of transferrin have a great influence on the biochemistry of plutonium in humans. Transferrin has a bacteriocidal effect on bacteria, in that it makes Fe3+ unavailable to the bacteria.Carbohydrate deficient transferrin increases in the blood with heavy ethanol consumption and can be monitored via laboratory testing. - Proteine/Peptide
