Human UCH-L1 Protein, His Tag, Unconjugated, E. coli
Artikelnummer:
ABS-UC1-H5140-1MG
Hersteller Artikelnummer:
UC1-H5140-1mg
Alternativnummer:
ABS-UC1-H5140-1MG
Hersteller:
AcroBiosystems
Wirt:
E. coli
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Ubiquitin carboxylterminal hydrolase isozyme L1 (UCHL1) ,a member of the peptidase C12 family, is also known as neuron cytoplasmic protein 9.5 (PGP 9.5) and ubiquitin thioesterase L1.About 30% of total UCHL1 is associated with membranes in brain. UCHL1 is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the Cterminal glycine of ubiquitin. Also,UCHL1 can bind to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATPindependent ubiquitin ligase activity. Furthermore, the mutations of UCHL1 gene can result in parkinson disease 5. - Proteine/Peptide
