Mouse VEGF R1 / Flt-1 Protein, Mouse IgG2a Fc Tag, low endotoxin, Unconjugated, Human
Artikelnummer:
ABS-VE1-M5256-1MG
Hersteller Artikelnummer:
VE1-M5256-1mg
Alternativnummer:
ABS-VE1-M5256-1MG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Mouse
Konjugation:
Unconjugated
Vascular endothelial growth factor receptor 1 (VEGFR1) is also known as Fmslike tyrosine kinase 1 (FLT1), Tyrosineprotein kinase receptor FLT, is a singlepass type I membrane protein and secreted protein which belongs to the protein kinase superfamily, Tyr protein kinase family and CSF1/PDGF receptor subfamily. VEGFR1 is detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues and specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. VEGFR1 acts as a cellsurface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR1 may play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. VEGFR1 can promote endothelial cell proliferation, survival and angiogenesis in adulthood. - Proteine/Peptide
