Human VEGF R2 / KDR Protein, Fc Tag (MALS verified), Unconjugated

Produktübersicht

• Artikelname: Human VEGF R2 / KDR Protein, Fc Tag (MALS verified), Unconjugated
• Artikelnummer: ABS-VE2-H5255-1MG
• Hersteller Artikelnummer: VE2-H5255-1mg
• Alternativnummer: ABS-VE2-H5255-1MG
• Hersteller: AcroBiosystems
• Wirt: Human
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Konjugation: Unconjugated

Produktbeschreibung

Kinase insert domain receptor (KDR) is also known as CD309, FLK1, VEGFR, VEGFR2, and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulinlike domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosinekinase domain. VEGFA binds to VEGFR1 (Flt1) and VEGFR2 (KDR/Flk1). VEGFR2 appears to mediate almost all of the known cellular responses to VEGF.The function of VEGFR1 is less well defined, although it is thought to modulate VEGFR2 signaling. Another function of VEGFR1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR2 binding (this appears to be particularly important during vasculogenesis in the embryo). In addition, VEGFR2 is able to interact with HIV1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposis sarcoma lesions. - Proteine/Peptide

Produkteigenschaften

• Molekulargewicht: 109.7 kDa
• Tag: C-Fc
• NCBI: 31823
• Puffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
• Reinheit: 95%
• Formulierung: Powder
• Target-Kategorie: VEGF R2

Bilder

Immobilized Human VEGF R2, Fc Tag (Cat. No. VE2-H5255) at 1 µg/mL (100 µL/well) can bind Anti-VEGFR2 Antibody, Mouse IgG1 with a linear range of 0.1-2 ng/mL (QC tested).

Human VEGF R2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.