Mouse VEGF R2 / KDR Protein, Mouse IgG2a Fc Tag, low endotoxin, Unconjugated, Human
Artikelnummer:
ABS-VE2-M5258-1MG
Hersteller Artikelnummer:
VE2-M5258-1mg
Alternativnummer:
ABS-VE2-M5258-1MG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Mouse
Konjugation:
Unconjugated
Kinase insert domain receptor (KDR) is also known as CD309, FLK1, VEGFR, VEGFR2, and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulinlike domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosinekinase domain. VEGFA binds to VEGFR1 (Flt1) and VEGFR2 (KDR/Flk1). VEGFR2 appears to mediate almost all of the known cellular responses to VEGF.The function of VEGFR1 is less well defined, although it is thought to modulate VEGFR2 signaling. Another function of VEGFR1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR2 binding (this appears to be particularly important during vasculogenesis in the embryo). In addition, VEGFR2 is able to interact with HIV1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposis sarcoma lesions. - Proteine/Peptide
