VSIG3, also known as IGSF11, BTIgSF, and CLMP, is a homophilic adhesion molecule that preferentially expressed in the brain. The function of VSIG3 is to stimulate cell growth through homophilic interactions. In clinical, the VSIG3 has been reported to as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. In addition, VSIG3 is also a ligand of B7 family member VISTA/PD1H and inhibits human Tcell functions through a novel VSIG3/VISTA pathway. VSIG3/VISTA coinhibitory pathway may provide new strategies for the treatment of human cancers and autoimmune disorders. - Proteine/Peptide
