Ebolavirus EBOV (subtype Zaire, strain Kikwit-95) Envelope Glycoprotein (GP) Protein, His Tag, Unconjugated, Human
Artikelnummer:
ABS-ZE5-V5221-1MG
Hersteller Artikelnummer:
ZE5-V5221-1mg
Alternativnummer:
ABS-ZE5-V5221-1MG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Virus
Konjugation:
Unconjugated
EBOV encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor (VP35), (VP40), GP, transcription activator (VP30), VP24, and RNA polymerase (L). GP protein contains 160kDa envelopeattached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfidelinked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (preGP) by cellular furin during virus assembly . GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DCSIGN and CLEC4M/DCSIGNR which act as cofactors for virus entry into the host cell. GP2 acts as a class I viral fusion protein. GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. sGP seems to possess an antiinflammatory activity as it can reverse the barrierdecreasing effects of TNF alpha. - Proteine/Peptide
