Functional Fas (human) Antibody, mAb (preservative free), Clone: [APO-1-3], Monoclonal

Produktübersicht

• Artikelname: Functional Fas (human) Antibody, mAb (preservative free), Clone: [APO-1-3], Monoclonal
• Artikelnummer: ABT-ADP0026-U050
• Hersteller Artikelnummer: ADP0026-U050
• Alternativnummer: ABT-ADP0026-U050-50UG
• Hersteller: Abcepta
• Kategorie: Antikörper
• Applikation: FC, IP, WB
• Spezies Reaktivität: Human
• Alternative Synonym: CD95, APO-1, TNFRSF6, Tumor Necrosis Factor Receptor Superfamily Member 6, Apoptosis-mediating Surface Antigen FAS

Produktbeschreibung

Fas (CD95) is a member of the death receptor (DR) family, a subfamily of the tumor necrosis factor receptor superfamily. The formation of the Fas death-inducing signaling complex (DISC) is the initial step of Fas signaling. Activation of procaspase-8 at the DISC leads to the induction of DR-mediated apoptosis. Stimulation of Fas has been also reported to trigger non-apoptotic pathways. It has been shown that membrane-bound FasL is essential for the cytotoxic activity, whereas soluble FasL appears to promote autoimmunity and tumorigenesis via induction of non-apoptotic pathways, in particular NF-kappa.

Produkteigenschaften

• Klonalität: Monoclonal
• Konzentration: 1mg/ml
• Klon-Bezeichnung: [APO-1-3]
• NCBI: 355
• UniProt: P25445
• Antibody Type: Monoclonal Antibody