MUC1 / EMA / CD227 (Epithelial Marker) Antibody - With BSA and Azide, Clone: [MUC1/845], Mouse, Monoclonal
Artikelnummer:
ABT-AH11873-U0100
Hersteller Artikelnummer:
AH11873-U0100
Alternativnummer:
ABT-AH11873-U0100-100UG
Hersteller:
Abcepta
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FC, IF, IHC
Spezies Reaktivität:
Human
Alternative Synonym:
Mucin-1, MUC-1, Breast carcinoma-associated antigen DF3, Cancer antigen 15-3, CA 15-3, Carcinoma-associated mucin, Episialin, H23AG, Krebs von den Lungen-6, KL-6, PEMT, Peanut-reactive urinary mucin, PUM, Polymorphic epithelial mucin, PEM, Tumor-associated epithelial membrane antigen, EMA, Tumor-associated mucin, CD227, Mucin-1 subunit alpha, MUC1-NT, MUC1-alpha, Mucin-1 subunit beta, MUC1-beta, MUC1-CT, MUC1, PUM
In Western blotting, it recognizes proteins in MW range of 265-400kDa, identified as different glycoforms of EMA. The alpha subunit has cell adhesive properties. It can act both as an adhesion and an anti-adhesion protein. EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain, which is involved in cell signaling, through phosphorylations and protein-protein interactions. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinoma tissues. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
