TTF-1 / NKX2.1 (Thyroid & Lung Epithelial Marker) Antibody - With BSA and Azide, Clone: [8G7G3/1 + NX2.1/690], Mouse, Monoclonal
Artikelnummer:
ABT-AH12422-U0100
Hersteller Artikelnummer:
AH12422-U0100
Alternativnummer:
ABT-AH12422-U0100-100UG
Hersteller:
Abcepta
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FC, IF, IHC-P
Spezies Reaktivität:
Human, Mouse, Rat
Alternative Synonym:
Homeobox protein Nkx-2.1, Homeobox protein NK-2 homolog A, Thyroid nuclear factor 1, Thyroid transcription factor 1, TTF-1, Thyroid-specific enhancer-binding protein, T/EBP, NKX2-1, NKX2A, TITF1, TTF1
Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.ĀLoss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.
