LIN28B Antibody, Clone: [1832CT281.64.17.75], Mouse, Monoclonal

Produktübersicht

• Artikelname: LIN28B Antibody, Clone: [1832CT281.64.17.75], Mouse, Monoclonal
• Artikelnummer: ABT-AM8635B
• Hersteller Artikelnummer: AM8635b
• Alternativnummer: ABT-AM8635B-200UL
• Hersteller: Abcepta
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human
• Alternative Synonym: Protein lin-28 homolog B, Lin-28B, LIN28B, CSDD2

Produktbeschreibung

Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5-GGAG-3 motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5-GGAG-3 motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [1832CT281.64.17.75]
• Molekulargewicht: 27084
• NCBI: 389421
• UniProt: Q6ZN17
• Formulierung: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
• Target-Kategorie: This LIN28B antibody is generated from a mouse immunized with a recombinant protein of human LIN28B.