Anti-Myosin 4/MyHC-IIB (C-terminus) Antibody, Rabbit, Polyclonal

Produktübersicht

• Artikelname: Anti-Myosin 4/MyHC-IIB (C-terminus) Antibody, Rabbit, Polyclonal
• Artikelnummer: ABT-AN1847
• Hersteller Artikelnummer: AN1847
• Alternativnummer: ABT-AN1847-100UL
• Hersteller: Abcepta
• Wirt: Rabbit
• Kategorie: Antikörper
• Alternative Synonym: Myh4, myosin Iib, myHC-2b, myosin heavy chain 4, MHC2B, Myhsf, MYH2B, AI506973, MyHC IIb

Produktbeschreibung

Non-muscle myosin II is an actin-based motor protein essential to cell motility, cell division, migration, adhesion and polarity. This myosin forms a hexameric complex comprised of two heavy chains (NMHC-II), two essential light chains, and two regulatory light chains (RLC). In vertebrates, there are three NMHC-II isoforms (NMHC-IIA, NMHC-IIB, and NMHC-IIC), which exhibit distinct patterns of expression in cells and tissues. Regulation of NMHC-II activity occurs through RLC and HC phosphorylation. RLCs are phosphorylated at Thr-18 and Ser-19, leading to activation of myosin II motor activity and increased myosin filament stability. By contrast, PKC phosphorylation of Ser-1/Ser-2 and Thr-9 in RLC may decrease activated myosin II interaction with actin. NMHC-II phosphorylation may be an important mode for regulating myosin-II assembly. PKC phosphorylates NMHC-IIA on Ser-1916 in the C-terminal region and NMHC-IIB on multiple serines in the tailpiece. Casein kinase II phosphorylates NMHC-IIA on Ser-1943 in the tailpiece and increases disassembly of NMHC-IIA filaments.

Produkteigenschaften

• Klonalität: Polyclonal
• Molekulargewicht: 222859
• NCBI: 17884
• UniProt: Q5SX39