Anti-PTP1B (Tyr-152), Phosphospecific Antibody, Rabbit, Polyclonal

Produktübersicht

• Artikelname: Anti-PTP1B (Tyr-152), Phosphospecific Antibody, Rabbit, Polyclonal
• Artikelnummer: ABT-AN1927
• Hersteller Artikelnummer: AN1927
• Alternativnummer: ABT-AN1927-100UL
• Hersteller: Abcepta
• Wirt: Rabbit
• Kategorie: Antikörper
• Alternative Synonym: PTPN1, TCPTP/PTPN2

Produktbeschreibung

PTP1B is a nonreceptor type protein tyrosine phosphatase that has essential roles in insulin and leptin signaling, as well as important functions in growth factor and integrin signaling. The structure of PTP1B includes a conserved phosphatase domain, C-terminal hydrophobic residues for targeting to the cytoplasmic face of the endoplasmic reticulum, and proline-rich regions characteristic of SH3 domain binding motifs. PTP1B can interact with N-Cadherin and dephosphorylate beta-catenin associated with cadherin complexes. PTP1B also interacts with Insulin and EGF receptors, and undergoes phosphorylation after receptor stimulation. Tyrosine phosphorylation at Tyr-66, Tyr-152, and Tyr-153 occurs after insulin receptor activation, and tyrosine phosphorylation of Tyr-152 may be required for interactions with N-Cadherin. In addition, Akt can phosphorylate Ser-50 and this phosphorylation can reduce PTP1B activity.

Produkteigenschaften

• Klonalität: Polyclonal
• Molekulargewicht: 49967
• NCBI: 5770
• UniProt: P18031