Anti-WAVE2 (Tyr-150) [conserved site], Phosphospecific Antibody, Rabbit, Polyclonal
Artikelnummer:
ABT-AN2025
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| Artikelname: | Anti-WAVE2 (Tyr-150) [conserved site], Phosphospecific Antibody, Rabbit, Polyclonal |
| Artikelnummer: | ABT-AN2025 |
| Hersteller Artikelnummer: | AN2025 |
| Alternativnummer: | ABT-AN2025-100UL |
| Hersteller: | Abcepta |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | WB |
| Alternative Synonym: | Wiskott-Aldrich syndrome verproline, Scar2, WASF2 |
| The Wiskott-Aldrich syndrome protein (WASP) family is involved in various pathways that regulate actin cytoskeletal organization. This family includes WASP, N-WASP, and three WAVE/SCAR isoforms, WAVE1, 2, and 3. WAVE proteins play key roles in actin-mediated cell events, such as membrane ruffling and lamellipodia formation. WAVEs contain an N-terminal WAVE homology domain, a basic domain, a Proline-rich region, and carboxy terminal verprolin, cofilin, and acidic (VCA) region. WAVEs are thought to act downstream of the Rac GTPase, connecting Rac activation to induction of Arp 2/3-mediated actin polymerization. Regulation of WAVE activity can occur through tyrosine phosphorylation. Src phosphorylation of WAVE1 at Tyr-125 enhances binding to the Arp2/3 complex, and is required for WAVE inhibition of Arp2/3-mediated stress fiber formation. By contrast, WAVE2 phosphorylation of Tyr-150 by Abl may enhance Arp2/3 complex actin nucleation and microspike formation in fibroblasts. Thus, site-specific tyrosine phosphorylation may be important for controlling specific activities of WAVE proteins. |
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