Anti-Nurr1 Antibody, Rabbit, Polyclonal
Artikelnummer:
ABT-AN2165
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| Artikelname: | Anti-Nurr1 Antibody, Rabbit, Polyclonal |
| Artikelnummer: | ABT-AN2165 |
| Hersteller Artikelnummer: | AN2165 |
| Alternativnummer: | ABT-AN2165-100UL |
| Hersteller: | Abcepta |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Alternative Synonym: | NR4A2, Nuclear receptor subfamily 4 group A member 2, Immediate-early response protein NOT, Orphan nuclear receptor NURR1, Transcriptionally-inducible nuclear receptor, NOT, NURR1, TINUR |
| The Nurr1 gene encodes a member of the steroid-thyroid hormone- retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinsons. Nurr1 is a stem cell marker and cooperates with PITX3 to promote terminal maturation of murine and human embryonic stem cell cultures to a midbrain dopamine neuron phenotype. In addition, Nurr1 is involved in the regulation of corticotropin-releasing hormone (CRH), which may be linked to and associated with rheumatoid arthritis. |
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