CDKN1A Antibody (C-term), Clone: [RB43822], Rabbit, Polyclonal

Produktübersicht

• Artikelname: CDKN1A Antibody (C-term), Clone: [RB43822], Rabbit, Polyclonal
• Artikelnummer: ABT-AP20797C
• Hersteller Artikelnummer: AP20797c
• Alternativnummer: ABT-AP20797C-400UL
• Hersteller: Abcepta
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human
• Alternative Synonym: Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6, p21, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1

Produktbeschreibung

May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.

Produkteigenschaften

• Klonalität: Polyclonal
• Klon-Bezeichnung: [RB43822]
• Molekulargewicht: 18119
• NCBI: 1026
• UniProt: P38936
• Target-Kategorie: This CDKN1A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 133-164 amino acids from the C-terminal region of human CDKN1A.