WT1 antibody, Clone: [R03797], Rabbit, Polyclonal

Produktübersicht

• Artikelname: WT1 antibody, Clone: [R03797], Rabbit, Polyclonal
• Artikelnummer: ABT-AP22434A
• Hersteller Artikelnummer: AP22434a
• Alternativnummer: ABT-AP22434A-200UL
• Hersteller: Abcepta
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human
• Alternative Synonym: Wilms tumor protein, WT33, WT1

Produktbeschreibung

Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5-GCG(T/G)GGGCG-3 (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921).

Produkteigenschaften

• Klonalität: Polyclonal
• Klon-Bezeichnung: [R03797]
• Molekulargewicht: 49188
• NCBI: 7490
• UniProt: P19544
• Formulierung: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Target-Kategorie: This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from human.