LAG3 antibody (N-term), Clone: [R03070], Rabbit, Polyclonal
Artikelnummer:
ABT-AP22459A
Produktübersicht
Artikelname:
LAG3 antibody (N-term), Clone: [R03070], Rabbit, Polyclonal
Artikelnummer:
ABT-AP22459A
Hersteller Artikelnummer:
AP22459a
Alternativnummer:
ABT-AP22459A-200UL
Hersteller:
Abcepta
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human, Mouse
Alternative Synonym:
Lymphocyte activation gene 3 protein, LAG-3, CD223, Secreted lymphocyte activation gene 3 protein, sLAG-3, LAG3 (HGNC:6476), FDC
Produktbeschreibung
Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:20421648, PubMed: 7805750, PubMed: 8647185). Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed: 20421648, PubMed: 7805750, PubMed: 8647185). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II), the precise role of MHC-II-binding is however unclear (PubMed: 8647185).
Produkteigenschaften
Klonalität:
Polyclonal
Klon-Bezeichnung:
[R03070]
Molekulargewicht:
57449
NCBI:
3902
UniProt:
P18627
Formulierung:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Target-Kategorie:
This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from human.
