PDPK1(S396) Antibody, Clone: [R04101NP], Rabbit, Polyclonal

Produktübersicht

• Artikelname: PDPK1(S396) Antibody, Clone: [R04101NP], Rabbit, Polyclonal
• Artikelnummer: ABT-AP22470A
• Hersteller Artikelnummer: AP22470a
• Alternativnummer: ABT-AP22470A-200UL
• Hersteller: Abcepta
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Alternative Synonym: 3-phosphoinositide-dependent protein kinase 1, hPDK1, 2.7.11.1, PDPK1, PDK1

Produktbeschreibung

Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9445477, PubMed:9707564, PubMed:9768361). Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), TSSK3, protein kinase PKN (PKN1 and PKN2) (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9707564, PubMed:9768361). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage (PubMed:10226025, PubMed:12167717, PubMed:9094314). Negatively r

Produkteigenschaften

• Klonalität: Polyclonal
• Klon-Bezeichnung: [R04101NP]
• Molekulargewicht: 63152
• NCBI: 5170
• UniProt: O15530
• Formulierung: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Target-Kategorie: This PDPK1(S396) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from the human region of human PDPK1(S396).