hIL1R-pY496, Clone: [R04087NP], Rabbit, Polyclonal

Produktübersicht

• Artikelname: hIL1R-pY496, Clone: [R04087NP], Rabbit, Polyclonal
• Artikelnummer: ABT-AP22476A-EV
• Hersteller Artikelnummer: AP22476a-ev
• Alternativnummer: ABT-AP22476A-EV-50UL
• Hersteller: Abcepta
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human
• Alternative Synonym: Interleukin-1 receptor type 1, IL-1R-1, IL-1RT-1, IL-1RT1, 3.2.2.6 {ECO:0000255|PROSITE-ProRule:PRU00204}, CD121 antigen-like family member A, Interleukin-1 receptor alpha, IL-1R-alpha, Interleukin-1 receptor type I, p80, CD121a, Interleukin-1 receptor type 1, membrane form, mIL-1R1, mIL-1RI, Interleukin-1 receptor type 1, soluble form, sIL-1R1, sIL-1RI, IL1R1, IL1R, IL1RA, IL1RT1

Produktbeschreibung

Receptor for IL1A, IL1B and IL1RN (PubMed:2950091, PubMed:37315560). After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa- B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).

Produkteigenschaften

• Klonalität: Polyclonal
• Klon-Bezeichnung: [R04087NP]
• Molekulargewicht: 65402
• NCBI: 3554
• UniProt: P14778
• Formulierung: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Target-Kategorie: This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from human.