ERAP1 Antibody, Rabbit, Polyclonal

Produktübersicht

• Artikelname: ERAP1 Antibody, Rabbit, Polyclonal
• Artikelnummer: ABT-AP51192
• Hersteller Artikelnummer: AP51192
• Alternativnummer: ABT-AP51192-100UL
• Hersteller: Abcepta
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human, Mouse, Rat
• Alternative Synonym: Endoplasmic reticulum aminopeptidase 1, 3411-, ARTS-1, Adipocyte-derived leucine aminopeptidase, A-LAP, Aminopeptidase PILS, Puromycin-insensitive leucyl-specific aminopeptidase, PILS-AP, Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, ERAP1, APPILS, ARTS1, KIAA0525

Produktbeschreibung

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

Produkteigenschaften

• Klonalität: Polyclonal
• NCBI: 51752
• UniProt: Q9NZ08