IL12B Antibody (C-term) Blocking Peptide

Produktübersicht

• Artikelname: IL12B Antibody (C-term) Blocking Peptide
• Artikelnummer: ABT-BP10463B
• Hersteller Artikelnummer: BP10463b
• Alternativnummer: ABT-BP10463B-500UG
• Hersteller: Abcepta
• Kategorie: Proteine/Peptide
• Alternative Synonym: Interleukin-12 subunit beta, IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, IL-12 subunit p40, NK cell stimulatory factor chain 2, NKSF2, IL12B, NKSF2

Produktbeschreibung

IL12B is a subunit of interleukin 12, a cytokinethat acts on T and natural killer cells, and has a broad array ofbiological activities. Interleukin 12 is a disulfide-linkedheterodimer composed of the 40 kD cytokine receptor like subunitencoded by this gene, and a 35 kD subunit encoded by IL12A. Thiscytokine is expressed by activated macrophages that serve as anessential inducer of Th1 cells development. This cytokine has beenfound to be important for sustaining a sufficient number ofmemory/effector Th1 cells to mediate long-term protection to anintracellular pathogen. Overexpression of this gene was observed inthe central nervous system of patients with multiple sclerosis(MS), suggesting a role of this cytokine in the pathogenesis of thedisease. The promoter polymorphism of this gene has been reportedto be associated with the severity of atopic and non-atopic asthmain children.

Produkteigenschaften

• NCBI: 3593
• UniProt: P29460
• Formulierung: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.