ENDOG is a nuclear encoded endonuclease that is localized in the mitochondrion. The protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA.
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Target-Kategorie:
The synthetic peptide sequence used to generate the antibody AP6571b was selected from the C-term region of human ENDOG. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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