TDG Antibody (C-term) Blocking Peptide

Produktübersicht

• Artikelname: TDG Antibody (C-term) Blocking Peptide
• Artikelnummer: ABT-BP6624B
• Hersteller Artikelnummer: BP6624b
• Alternativnummer: ABT-BP6624B-500UG
• Hersteller: Abcepta
• Kategorie: Proteine/Peptide
• Alternative Synonym: G/T mismatch-specific thymine DNA glycosylase, Thymine-DNA glycosylase, hTDG, TDG

Produktbeschreibung

The protein TDG belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine.

Produkteigenschaften

• NCBI: 6996
• UniProt: Q13569
• Formulierung: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
• Target-Kategorie: The synthetic peptide sequence used to generate the antibody AP6624b was selected from the C-term region of human TDG. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.