Insulin-like growth factor-binding protein 4, IBP-4, IGF-binding protein 4, IGFBP-4, IGFBP4, IBP4
This gene is a member of the insulin-like growth factorbinding protein (IGFBP) family and encodes a protein with an IGFBPdomain and a thyroglobulin type-I domain. The protein binds bothinsulin-like growth factors (IGFs) I and II and circulates in theplasma in both glycosylated and non-glycosylated forms. Binding ofthis protein prolongs the half-life of the IGFs and alters theirinteraction with cell surface receptors.