TRRAP, a member of the TRA1 subfamily of the PI3/PI4 kinase family, is an adapter protein found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. It plays a central role in MYC (c-Myc) transcription activation, and also participates in cell transformation by MYC. TRRAP is required for p53/TP53-, E2F1- and E2F4-mediated transcription activation, and is also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. It likely performs by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Although probably not required in the steps following histone acetylation in processes of transcription activation, it may be required for the mitotic checkpoint and normal cell cycle progression. It is a component of various HAT complexes, including the PCAF, TFTC, TIP60 STAGA and BAF53 complexes. The PI3K/PI4K domain of this nuclear protein is required for the recruitment of HAT complexes, and the MYC-dependent transactivation. Although it is strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, and lacks such activity.
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Target-Kategorie:
The synthetic peptide sequence used to generate the antibody AP8056c was selected from the Center region of human TRRAP . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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