Nucleoside diphosphate kinase A, NDK A, NDP kinase A, Granzyme A-activated DNase, GAAD, Metastasis inhibition factor nm23, NM23-H1, Tumor metastatic process-associated protein, NME1, NDPKA, NM23
NME1 was identified because of its reduced mRNA transcript levels in highly metastatic cells. NME1 encodes the A isoform of nucleoside diphosphate kinase (NDK). NDK exists as a hexamer composed of the A (NME1) and B (encoded by NME2) isoforms. Mutations in NME1 have been identified in aggressive neuroblastomas.