In Drosophila, neuroblasts divide asymmetrically intoanother neuroblast at the apical side and a smaller ganglion mothercell on the basal side. Cell polarization is precisely regulated by2 apically localized multiprotein signaling complexes that aretethered by Inscuteable, which regulates their apical localization(Izaki et al., 2006 [PubMed 16458856]).