SARS-CoV-2 ORF1ab Peptide (YQCGHYKHITSKETL)
Artikelnummer:
ABT-VGP1351
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| Artikelname: | SARS-CoV-2 ORF1ab Peptide (YQCGHYKHITSKETL) |
| Artikelnummer: | ABT-VGP1351 |
| Hersteller Artikelnummer: | VGP1351 |
| Alternativnummer: | ABT-VGP1351-100UG |
| Hersteller: | Abcepta |
| Kategorie: | Proteine/Peptide |
| Alternative Synonym: | 3CL-PRO, 3CLp, EC 2.1.1.- (Non-structural protein 16, EC 2.7.7.48 (Non-structural protein 12, EC 3.1.-.- (NendoU) (Non-structural protein 15, EC 3.1.13.- (Guanine-N7 methyltransferase) (Non-structural protein 14, EC 3.4.19.12, EC 3.4.22.- (PL2-PRO) (Papain-like proteinase, EC 3.4.22.69 (Main protease, EC 3.6.4.12, EC 3.6.4.13 (Non-structural protein 13, ExoN, GFL), RNA-directed RNA polymerase, Hel, Mpro) (Non-structural protein 5, PL-PRO), Non-structural protein 4, Pol, RdRp, Replicase polyprotein 1ab, nsp1), Non-structural protein 2, nsp10 (Growth factor-like peptide, nsp12), Helicase, nsp13), Proofreading exoribonuclease, nsp14), Uridylate-specific endoribonuclease, nsp15), 2-O-methyltransferase, nsp16) ], nsp2 (p65 homolog), Non-structural protein 3, nsp3, nsp4, 3C-like proteinase, nsp5) (SARS coronavirus main proteinase), Non-structural protein 6, nsp6, Non-structural protein 7, nsp7, Non-structural protein 8, nsp8, Non-structural protein 9, nsp9, Non-structural protein 10, pp1ab (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor nsp1 (Leader protein) (Non-structural protein 1, sars-cov-2 |
| SARS-CoV-2 is part of the Coronaviridae family, whose members are named after their crown-like appearance under the electron microscope caused by the surface glycoproteins that decorate the virus. Coronaviruses have a large (30+ kb) single-stranded positivesense RNA genome encoding for several open reading frames. The open reading frame ORF1ab is the source for replicase, replicase/transcriptase, and polymerase polyproteins. ORF1ab is translated into ORF1a and ORF1b polyproteins in the host cell. Virus-encoded proteinases including 3C like protease cleaveORF1 into multiple nonstructural proteins (nsps). ORF1a yields protein products nsp 1 to nsp 10, which play at role in response to cellular stresses and maintaining integrity of the cellular components, along with crucial roles in viral replication. ORF1b encodes viral RNA-dependent RNA polymerase, helicase, exonuclease, auridylate specific endonuclease, and methyl transferase . THe significant contribution of these proteins to viral pathogenesis makes them promising targets for anti-viral therapeutics and vaccine development. |
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