Anti-Transthyretin 56-61, amyloid specific (mouse monoclonal), IgG1, Mouse, Monoclonal

Produktübersicht

• Artikelname: Anti-Transthyretin 56-61, amyloid specific (mouse monoclonal), IgG1, Mouse, Monoclonal
• Artikelnummer: AGR-AS16-3113
• Hersteller Artikelnummer: AS16-3113
• Alternativnummer: AGR-AS16-3113
• Hersteller: Agrisera
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: ELISA, IHC, WB
• Spezies Reaktivität: Human
• Immunogen: Recombinant protein corresponding to the Human wild type Transthyretin. GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE The epitope has been mapped to residue 56-61

Produktbeschreibung

Transthyretin (TTR), formerly known as Prealbumin, is in vivo involved in the binding and transportation of the Thyroxin hormone and retinol-binding protein. Mutations in TTR are associated with familial amyloidotic polyneuropathy (FAP) which is a fatal

Produkteigenschaften

• Klonalität: Monoclonal
• Molekulargewicht: 155
• Isotyp: IgG1
• Reinheit: Affinity purified in PBS pH 7.4.
• Formulierung: Lyophilized
• Antibody Type: Monoclonal Antibody

Anwendungsbeschreibung

• Application Verdünnung: 1:1000 (ELISA), 1:500 (IHC), 1:1000 (WB)
• Anwendungsbeschreibung: Specifically reactive to the amyloid form of human Transthyretin. Epitope mapped to residue 56-61 which remains buried within the native fold of transthyretin but becomes exposed within its amyloid form.It has been suggested that that two distinct mechanisms of TTR-amyloidosis exists. The first, most common seen in wild type TTR Amyloidosis, consists of the full length TTR. Whereas the other type of amyloidosis mainly consists of the C-terminal region of the protein and is more common in mutant versions of TTR. Mouse IgG1 Anti-Transthyretin 56-61 (Amyloid Specific) epitope is located at the C-terminal strand of cleaved TTR and is suitable to detect amyloid formation derived from the C-terminal.