NE 52-QQ57 is an orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 significantly inhibited the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).
Molekulargewicht:
416.52
Reinheit:
>99%
CAS Nummer:
[1401728-56-0]
Formel:
C24H28N6O
Target-Kategorie:
GPR/FFAR
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