TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-beta1 with an IC50 value of 8.68 nM.
Molekulargewicht:
334.85
Reinheit:
>99%
CAS Nummer:
[864374-00-5]
Formel:
C14H11ClN4S2
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten