MeBIO, an analog of 6-bromoindirubin-3-oxime, has been suggested to possess the structural basis for a potent and selective inhibitor of glycogen synthase kinase-3 (GSK3) and cyclin-dependent kinases. MeBIO displays minimal activity against CDK1/Cyclin B, GSK-3, and CDK5/p25 (IC50 values are 92.0, 44-100 and >100 µM respectively). MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist.
Molekulargewicht:
370.20
Reinheit:
>98%
CAS Nummer:
[667463-95-8]
Formel:
C17H12BrN3O2
Target-Kategorie:
GSK-3
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