Apostatin-1 (Apt-1) is a new type of TRADD inhibitor. Apostatin 1 can bind to TRADD-N (KD=2.17 µM), and destroy the binding of Apostatin 1 to TRADD-C and TRAF2. Apostatin-1 regulates ubiquitination of RIPK1 and beclin 1. By activating autophagy in cells accumulated by mutated tau, alpha-synuclein or huntingtin, Apostatin 1 blocked apoptosis and restored homeostasis.
Molekulargewicht:
345.51
Reinheit:
>99.0%
CAS Nummer:
[2559703-06-7]
Formel:
C19H27N3OS
Target-Kategorie:
RIPK
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