Niraparib (MK-4827), CAS [[1038915-60-4]]

Produktübersicht

• Artikelname: Niraparib (MK-4827), CAS [[1038915-60-4]]
• Artikelnummer: AMO-M2215
• Hersteller Artikelnummer: M2215
• Alternativnummer: AMO-M2215-5MG,AMO-M2215-10MG,AMO-M2215-50MG
• Hersteller: Abmole Bioscience
• Kategorie: Biochemikalien
• Alternative Synonym: MK-4827

Produktbeschreibung

MK-4827 (Niraparib) is a selective PARP1/2 inhibitor with an IC50 value of 3.8 nM/2.1 nM that increases the formation of PARP-DNA complexes through inhibition of PARPase activity, leading to DNA damage, apoptosis, PARP-1-dependent cell death (parthanatos) and cell death. Strong effector activity when acting on cancer cells harboring mutant BRCA-1 and BRCA-2. It is more than 330-fold more selective than PARP3, V-PARP and Tank1.

Produkteigenschaften

• Molekulargewicht: 320.39
• Reinheit: 99.82%
• CAS Nummer: [1038915-60-4]
• Formel: C19H20N4O
• Target-Kategorie: PARP