Crovalimab (SKY59, RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 µM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 µM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research.
Reinheit:
>98.5%
CAS Nummer:
[1917321-26-6]
Target-Kategorie:
Complement System
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