PU02 (NMMP) is a potent and selective negative allosteric modulator (NAM) of 5-HT3 receptor, displaying IC50 values of ~1 µM at 5-HT(3)Rs and substantially lower activities at other Cys-loop receptors. PU02 inhibits the proliferation of hepatocellular carcinoma (HepG2) cells associated with G2/M phase cell cycle arrest, and reduced cyclin-dependent kinase (CDK) 4 and cyclin B1/D1 levels.
Molekulargewicht:
292.36
Reinheit:
>99.0%
CAS Nummer:
[313984-77-9]
Formel:
C16H12N4S
Target-Kategorie:
5-HT Receptor
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