GSK-J4 hydrochloride, CAS [[1797983-09-5]]

Produktübersicht

• Artikelname: GSK-J4 hydrochloride, CAS [[1797983-09-5]]
• Artikelnummer: AMO-M2731
• Hersteller Artikelnummer: M2731
• Alternativnummer: AMO-M2731-5MG,AMO-M2731-10MG,AMO-M2731-25MG,AMO-M2731-50MG
• Hersteller: Abmole Bioscience
• Kategorie: Biochemikalien

Produktbeschreibung

GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 µM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-alpha production in human primary macrophages with an IC50 of 9 µM. GSK J4 hydrochloride is a cell permeable procompound of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM and inactive against a panel of demethylases of the JMJ family.

Produkteigenschaften

• Molekulargewicht: 453.96
• Reinheit: 98.95%
• CAS Nummer: [1797983-09-5]
• Formel: C24H27N5O2.HCl
• Target-Kategorie: Histone demethylase