| OAC1 (Oct4-activating compound 1) is a potent Oct4 activator that activates both the Oct4 and Nanog promoters, promotes induced multifunctional stem cell (iPSC) formation, and activates OCT4 through upregulation of HOXB4 expression.Additionally, OAC1 increases the transcription of the Oct4-Nanog-Sox2 triplet and TET1 and promotes cell reprogramming by increasing efficiency and shortening reprogramming time. and TET1 transcription, and may promote cell reprogramming by increasing efficiency and shortening reprogramming time. |
