CDK12-IN-2 is a potent, selective and nanomolar CDK12 inhibitor (IC50=52 nM). CDK12-IN-2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12-IN-2 inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II. CDK12-IN-2 can be used an excellent chemical probe for functional studies of CDK12.
Molekulargewicht:
532.64
Reinheit:
99.0%
CAS Nummer:
[2244987-03-7]
Formel:
C32H32N6O2
Target-Kategorie:
CDK
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