G5-7 is an orally active and allosteric JAK2 inhibitor, selectively inhibits JAK2 mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 induces cell cycle arrest, apoptosis and possesses antiangiogenic effect. G5-7 has the potential for glioma study.
Molekulargewicht:
383.39
Reinheit:
99.0%
CAS Nummer:
[939681-36-4]
Formel:
C22H19F2NO3
Target-Kategorie:
JAK
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