Capmatinib dihydrochloride hydrate, CAS [[1865733-40-9]]

Produktübersicht

• Artikelname: Capmatinib dihydrochloride hydrate, CAS [[1865733-40-9]]
• Artikelnummer: AMO-M54609
• Hersteller Artikelnummer: M54609
• Alternativnummer: AMO-M54609-5MG,AMO-M54609-10MG,AMO-M54609-50MG,AMO-M54609-100MG
• Hersteller: Abmole Bioscience
• Kategorie: Biochemikalien
• Alternative Synonym: INC280 dihydrochloride hydrate, INCB-28060 dihydrochloride hydrate

Produktbeschreibung

Capmatinib dihydrochloride hydrate is a potent, orally active, selective, ATP-competitive c-Met kinase inhibitor (IC50=0.13 nM) that inhibits the phosphorylation of c-MET, as well as downstream effector proteins of the c-MET pathway, such as ERK1/2, AKT, FAK, In addition, Capmatinib dihydrochloride hydrate effectively inhibited the proliferation and migration of c-Met-dependent tumor cells, induced apoptosis, and demonstrated antitumor activity in a mouse model of tumor. Capmatinib dihydrochloride hydrate is mainly metabolized by CYP3A4 and aldehyde oxidase.

Produkteigenschaften

• Molekulargewicht: 503.00
• Reinheit: >99.0%
• CAS Nummer: [1865733-40-9]
• Formel: C23H21Cl2FN6O2
• Target-Kategorie: c-Met