SRI-41315 inhibits PTCs (premature termination codons) associated with cystic fibrosis in permanent and primary human bronchial epithelial cells by inducing a prolonged stoppage of the termination codon, restoring the expression and function of cystic fibrosis transmembrane conductance regulator (CFTR). In addition, SRI-41315 enhances aminoglycoside-mediated passaging, leading to a synergistic increase in CFTR activity.
Molekulargewicht:
357.00
Reinheit:
>99.0%
CAS Nummer:
[1613509-49-1]
Formel:
C22H19N3O2
Target-Kategorie:
CFTR
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