Pleiotrophin (PTN) is a secreted, strongly heparinbinding, developmentally regulated cytokine. PTN is involved in development of brain, bone, and organs undergoing branching morphogenesis. PTN causes PTPRB dimerization and inactivates its phosphatase activity, which allows increased tyrosine phosphorylation of its substrates. Increased expression of PTN is correlated with neuronal development or stresses such as brain ischemia and Parkinsons disease.
Reinheit:
>95%, Endotoxin < 1 EU/µg
CAS Nummer:
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Target-Kategorie:
Cytokines and Growth Factors
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