PABPN1 Blocking peptide (Middle region)
Artikelnummer:
ASB-AAP81061
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| Artikelname: | PABPN1 Blocking peptide (Middle region) |
| Artikelnummer: | ASB-AAP81061 |
| Hersteller Artikelnummer: | AAP81061 |
| Alternativnummer: | ASB-AAP81061-100UG |
| Hersteller: | Aviva |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Alternative Synonym: | OPMD, PAB2, PABII, PABP2, PABP-2 |
| This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3 ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5 end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. |
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