The function remains unknown.This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells.
TFAM antibody - N-terminal region (ARP31400_P050) validated by WB using bEND3 cell lysate at lane1:10 ug, lane2:20 ug.
TFAM antibody - N-terminal region (ARP31400_P050) validated by WB using bEND3 cell lysate at lane1:10 ug, lane2:20 ug.
Lanes: Lane 1 and 2: HepG2 cell lysate Lane 3 and 4: Hep3B cell lysate Lane 5 and 6: K562 cell lysate Primary Antibody Dilution: 1:1000 Secondary Antibody: