EAP30 Antibody - N-terminal region

Produktübersicht

• Artikelname: EAP30 Antibody - N-terminal region
• Artikelnummer: ASB-ARP31531_P050
• Hersteller Artikelnummer: ARP31531_P050
• Alternativnummer: ASB-ARP31531_P050-25UL,ASB-ARP31531_P050-100UL
• Hersteller: Aviva
• Wirt: Rabbit
• Kategorie: Proteine/Peptide
• Applikation: IHC, WB
• Spezies Reaktivität: Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human EAP30
• Alternative Synonym: Dot3, EAP30, VPS22

Produktbeschreibung

ELL encodes an RNA polymerase II transcription factor that undergoes frequent translocation in acute myeloid leukemia (AML). In addition to its elongation activity, ELL contains a novel type of RNA polymerase II interaction domain that is capable of repressing polymerase activity in promoter-specific transcription. EAP30 is a subunit of the ELL complex. EAP30 can interact with ELL and derepress ELLs inhibitory activity in vitro.SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL, MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741], Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM].

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 0.5 mg/ml
• Molekulargewicht: 29kDa
• NCBI: 11267
• UniProt: Q96H20
• Formulierung: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Bilder

Anti-SNF8 / EAP30 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. EAP30 Antibody ARP31531_P050 concentration 5 ug/ml.

Anti-SNF8 / EAP30 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. EAP30 Antibody ARP31531_P050 concentration 5 ug/ml.

Rabbit Anti-EAP30 Antibody
Catalog Number: ARP31531
Paraffin Embedded Tissue: Human Stomach
Cellular Data: Epithelial cells of Fundic Gland and Surface Mucous Cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X

WB Suggested Anti-EAP30 Antibody Titration: 5.0ug/ml
Positive Control: HepG2 cell lysateSNF8 is supported by BioGPS gene expression data to be expressed in HepG2

EAP30 antibody - N-terminal region (ARP31531_P050) in Human HepG2 using Western Blot